Figures

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Weekly admissions, available outcome data, organ support

Age and sex distribution (for period 2020-07-06 to 2020-08-02)

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Organ support required (at admission)

Organ support duration (for those patients that received organ support)

Tables - Patient Characteristics

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Patient characteristics: demographics (period 2020-07-06 to 2020-08-02; total admissions n=22)
Age at admission in years [n=22 (100.0%)]
Mean (SD)	47.59	(20.55)
Median (IQR)	47.25	(37.80,62.10)
Sex, n (%) [n=22 (100.0%)]
Female	3	(13.6%)
Male	19	(86.4%)
Pregnancy status, n (% of females) [n=2 (66.7%)]
Not known to be pregnant	2	(100.0%)
Recently pregnant	0	( 0.0%)
Currently pregnant	0	( 0.0%)
Body mass index categories, n (%) [n=22 (100.0%)]
<18.5	10	(45.5%)
18.5-<25	8	(36.4%)
25-<30	3	(13.6%)
30-<40	1	( 4.5%)
40+	0	( 0.0%)

Patient characteristics: medical history (period 2020-07-06 to 2020-08-02; total admissions n=22)
Dependency prior to admission, n (%) [n=22 (100.0%)]
Able to live without assistance in daily activities	9	(40.9%)
Minor assistance with some daily activities	13	(59.1%)
Major assistance with majority of or all daily activities	0	( 0.0%)
Total assistance with all daily activities	0	( 0.0%)
HIV, n (%) [n=16 (72.7%)]
No HIV	10	(62.5%)
ART compliant	5	(31.2%)
ART non-compliant	0	( 0.0%)
Not on ART	1	( 6.2%)
TB, n (%) [n=22 (100.0%)]
No TB	21	(95.5%)
TB	1	( 4.5%)
Hyptertension, n (%) [n=20 (90.9%)]
No severe hypertension	20	(100.0%)
Hypertension	0	( 0.0%)
Congestive cardiac failure, n (%) [n=22 (100.0%)]
No congestive cardiac failure	22	(100.0%)
Congestive cardiac failure	0	( 0.0%)
Stroke, n (%) [n=22 (100.0%)]
No stroke	22	(100.0%)
Stroke	0	( 0.0%)
Diabetes, n (%) [n=22 (100.0%)]
No diabetes	22	(100.0%)
On insulin	0	( 0.0%)
On tablets	0	( 0.0%)
Not on treatment	0	( 0.0%)

Patient characteristics: acute severity (period 2020-07-06 to 2020-08-02; total admissions n=22)
NEWS2 score [n=22 (100.0%)]
Median (IQR)	6.5	(5.25,9.75)	(5.25,9.75)
UVA score [n=16 (72.7%)]
Median (IQR)	2.5	(1,5)	(1,5)
PF ratio [n=22 (100.0%)]
Mean (SD)	31.03	(13.23)	(13.23)
Median (IQR)	23.39	(20.62,44.41)	(20.62,44.41)
[0,13.3)	0	( 0.0%)	(0.0%)
[13.3,26.7)	12	(54.5%)	(54.5%)
[26.7,Inf)	10	(45.5%)	(45.5%)

Tables - Outcomes

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Patient outcomes (period 2020-07-06 to 2020-08-02; total admissions n=22)
Outcome at the end of critical care, n (%) [n=22 (100.0%)]
Discharged	13	(59.1%)
Died	6	(27.3%)
Absconded	0	( 0.0%)
Unknown	3	(13.6%)
Length of stay [n=20 (90.9%)]
Mean (SD)	4.05	(2.61)
Median (IQR)	3.50	(2.00,6.00)
Length of stay (critical care survivors; N=13) [n=13 (100.0%)]
Mean (SD)	3.46	(2.67)
Median (IQR)	3.00	(2.00,4.00)
Length of stay (critical care non survivors; N=6) [n=6 (100.0%)]
Mean (SD)	5.17	(2.48)
Median (IQR)	5.50	(3.50,6.00)
Organ support (at any time during critical care stay), n (%) [n=22 (100.0%)]
Oxygen	20	(90.9%)
Fluid balance	10	(45.5%)
Neurological observation	5	(22.7%)
Intravenous drug (not vasoactive)	2	( 9.1%)
Intravenous drug (vasoactive)	0	( 0.0%)
Continuous monitoring	20	(90.9%)
Intubation & ventilation	2	( 9.1%)
Other	9	(40.9%)
Duration of oxygen support (days) [n=20 (100.0%)]
Mean (SD)	2.85	(2.11)
Median (IQR)	2.00	(1.00,3.25)
Duration of fluid balance (days) [n=10 (100.0%)]
Mean (SD)	3.10	(2.38)
Median (IQR)	2.00	(1.00,5.75)
Duration of neurological observation (days) [n=5 (100.0%)]
Mean (SD)	1.40	(0.55)
Median (IQR)	1.00	(1.00,2.00)
Duration of intravenous drug administration (not vasoactive) (days) [n=2 (100.0%)]
Mean (SD)	1.00	(0.00)
Median (IQR)	1.00	(1.00,1.00)
Duration of intravenous drug administration (vasoactive) (days) [n=0 (NaN%)]
Mean (SD)	NaN	(-)
Median (IQR)	–	(-,-)
Duration of continuous monitoring (days) [n=20 (100.0%)]
Mean (SD)	2.70	(2.30)
Median (IQR)	1.50	(1.00,3.25)
Duration of intubation & ventilation (days) [n=2 (100.0%)]
Mean (SD)	1.00	(0.00)
Median (IQR)	1.00	(1.00,1.00)
Duration of other organ support (days) [n=9 (100.0%)]
Mean (SD)	2.11	(1.05)
Median (IQR)	2.00	(1.00,3.00)

Patient characteristics by outcome (period 2020-07-06 to 2020-08-02; total admissions n=22)
	Discharged (hospital)		Discharged (critical care), died in hospital		Died in critical care		Discharged (critical care), outcome unknown		Outcome unknown

Age [n=22 (100.0%)]
0-29	0	(0.0%)	0	(0.0%)	1	(50.0%)	0	(0.0%)	0	(0.0%)
30-39	0	(0.0%)	0	(0.0%)	1	(16.7%)	0	(0.0%)	0	(0.0%)
40-49	0	(0.0%)	0	(0.0%)	0	( 0.0%)	0	(0.0%)	0	(0.0%)
50-59	0	(0.0%)	0	(0.0%)	2	(66.7%)	0	(0.0%)	0	(0.0%)
60+	0	(0.0%)	0	(0.0%)	2	(28.6%)	0	(0.0%)	0	(0.0%)
Sex [n=22 (100.0%)]
Female	0	(0.0%)	0	(0.0%)	0	( 0.0%)	0	(0.0%)	0	(0.0%)
Male	0	(0.0%)	0	(0.0%)	6	(31.6%)	0	(0.0%)	0	(0.0%)
BMI [n=22 (100.0%)]
<18.5	0	(0.0%)	0	(0.0%)	2	(20.0%)	0	(0.0%)	0	(0.0%)
18.5-<25	0	(0.0%)	0	(0.0%)	2	(25.0%)	0	(0.0%)	0	(0.0%)
25-<30	0	(0.0%)	0	(0.0%)	2	(66.7%)	0	(0.0%)	0	(0.0%)
30-<40	0	(0.0%)	0	(0.0%)	0	( 0.0%)	0	(0.0%)	0	(0.0%)
40+	0	(NaN%)	0	(NaN%)	0	( NaN%)	0	(NaN%)	0	(NaN%)
HIV status [n=16 (72.7%)]
No HIV	0	(0.0%)	0	(0.0%)	2	( 20.0%)	0	(0.0%)	0	(0.0%)
ART compliant	0	(0.0%)	0	(0.0%)	1	( 20.0%)	0	(0.0%)	0	(0.0%)
ART non-compliant	0	(NaN%)	0	(NaN%)	0	( NaN%)	0	(NaN%)	0	(NaN%)
Not on ART	0	(0.0%)	0	(0.0%)	1	(100.0%)	0	(0.0%)	0	(0.0%)
TB status [n=22 (100.0%)]
No TB	0	(0.0%)	0	(0.0%)	5	( 23.8%)	0	(0.0%)	0	(0.0%)
TB	0	(0.0%)	0	(0.0%)	1	(100.0%)	0	(0.0%)	0	(0.0%)
NEWS2 score [n=22 (100.0%)]
Mean (SD)	–	(-)	–	(-)	9.83	(2.14)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	10.50	( 9.25,11.00)	–	(-,-)	–	(-,-)
UVA score [n=16 (72.7%)]
Mean (SD)	–	(-)	–	(-)	3.50	(1.91)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	4.00	(2.50,5.00)	–	(-,-)	–	(-,-)
Length of stay (days) [n=20 (90.9%)]
Mean (SD)	–	(-)	–	(-)	5.17	(2.48)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	5.50	(3.50,6.00)	–	(-,-)	–	(-,-)
Organ support (at any time during critical care) [n=22 (100.0%)]
Oxygen	0	(0.0%)	0	(0.0%)	6	(30.0%)	0	(0.0%)	0	(0.0%)
Fluid balance	0	(0.0%)	0	(0.0%)	4	(40.0%)	0	(0.0%)	0	(0.0%)
Neurological observation	0	(0.0%)	0	(0.0%)	3	(60.0%)	0	(0.0%)	0	(0.0%)
Intravenous drug (not vasoactive)	0	(0.0%)	0	(0.0%)	1	(50.0%)	0	(0.0%)	0	(0.0%)
Intravenous drug (vasoactive)	0	(NaN%)	0	(NaN%)	0	( NaN%)	0	(NaN%)	0	(NaN%)
Continuous monitoring	0	(0.0%)	0	(0.0%)	6	(30.0%)	0	(0.0%)	0	(0.0%)
Intubation & ventilation	0	(0.0%)	0	(0.0%)	1	(50.0%)	0	(0.0%)	0	(0.0%)
Other	0	(0.0%)	0	(0.0%)	2	(22.2%)	0	(0.0%)	0	(0.0%)
Duration of oxygen support (days) [n=20 (100.0%)]
Mean (SD)	–	(-)	–	(-)	4.00	(2.45)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	3.00	(2.25,5.25)	–	(-,-)	–	(-,-)
Duration of fluid balance (days) [n=10 (100.0%)]
Mean (SD)	–	(-)	–	(-)	4.00	(2.45)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	4.50	(2.50,6.00)	–	(-,-)	–	(-,-)
Duration of neurological observation (days) [n=5 (100.0%)]
Mean (SD)	–	(-)	–	(-)	1.67	(0.58)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	2.00	(1.50,2.00)	–	(-,-)	–	(-,-)
Duration of intravenous drug administration (not vasoactive) (days) [n=2 (100.0%)]
Mean (SD)	–	(-)	–	(-)	1.00	(-)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	1.00	(1.00,1.00)	–	(-,-)	–	(-,-)
Duration of intravenous drug administration (vasoactive) (days) [n=0 (NaN%)]
Mean (SD)	–	(-)	–	(-)	–	(-)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	–	(-,-)	–	(-,-)	–	(-,-)
Duration of continuous monitoring (days) [n=20 (100.0%)]
Mean (SD)	–	(-)	–	(-)	4.00	(2.45)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	3.00	(2.25,5.25)	–	(-,-)	–	(-,-)
Duration of intubation & ventilation (days) [n=2 (100.0%)]
Mean (SD)	–	(-)	–	(-)	1.00	(-)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	1.00	(1.00,1.00)	–	(-,-)	–	(-,-)
Duration of other organ support (days) [n=9 (100.0%)]
Mean (SD)	–	(-)	–	(-)	2.50	(0.71)	–	(-)	–	(-)
Median (IQR)	–	(-,-)	–	(-,-)	2.50	(2.25,2.75)	–	(-,-)	–	(-,-)